The cause of the rapid development of Alzheimer’s disease

Lack of sleep adversely affects people suffering from Alzheimer’s. In this case, “garbage protein” spreads faster in the brain of people and contributes to the accelerated development of dementia. The same can happen with people with Parkinson’s syndrome. Scientists wrote about this in the Science Journal.
“All people should get enough sleep – our brain needs to rest from daytime stress. We don’t know yet whether it is possible to protect yourself from Alzheimer’s disease by observing the correct sleep patterns, but in any case it will not harm you and slow down brain degeneration if the process has already begun, said a researcher from Washington University in St. Louis. Holtzman.

Alzheimer’s and Parkinson’s diseases begin due to the accumulation of various “protein debris” in the nerve cells. Gradually, neurons die in different parts of the brain. It leads to senile dementia and memory loss in Alzheimer’s disease and inability to control limbs in the second case.
Until now, scientists can not understand the mechanisms that cause brain cells to accumulate beta-amyloid plaques, alpha-synuclein tangles and  tau protein. There is no cure for these diseases, because of this.

Holtzman and his colleagues have been conducting research on this topic for many years. Recently, scientists have suggested that the concentration of tau protein was higher in cells in those older people who suffered from insomnia. Thus, the researchers concluded that lack of sleep helps to accelerate the development of the disease.

To confirm their theory, experts conducted a study with mice. They were divided into two groups. One lived on a normal daily routine. Other scientists were deprived of sleep when they introduced one of the antipsychotics into their bodies.

It turned out that the concentration of tau protein in rodents depended on the time of day. During the day, when the rodents are sleeping, it was about two times lower than at night. According to biologists, such differences were absent in the rodents of the second group, who were fed the drug and forced to sleep for a long time.

As a result, it turned out that the protein concentration was higher in those who had trouble sleeping. This idea was confirmed during the experiment with people.
Scientists have obtained similar results in the study of the spread of another type of “garbage protein” – alpha synuclein tangles. With the development of Parkinson’s they accumulate in the brain. In such cases, sick people also disrupted sleep.

This website uses cookies.