British biologists from the University of Cambridge have discovered a number of genetic mutations in people who significantly influence the process of weight formation. To do this, they had to study the DNA of thousands of people with different body weights, reports PLoS Genetics. One of the authors of the study, Sadaf Faruki, analyzed the DNA of ten thousand British people with normal weight, two thousand obese people and as many people too thin for their complexion.
Comparing the genomes of these groups of people, scientists have identified thirteen minor mutations that can significantly influence the formation of excess weight. Faruki noted that ten of them had been tied to the weight gain before, and three more were discovered during the study.
In this case, mutations in different genes in different ways influenced the weight of people. For example, changes in the “obesity gene” FTO doomed a person to the rapid accumulation of fat, and the CADM2 gene, which affects brain receptors, on the contrary, significantly added to people the tendency to thinness.
Biologists were not able to understand exactly how the found mutations work and what they influence, but they hope to find out in the course of further observation of the experiment participants.
We showed for the first time that thin people remain so mainly because their genome, on average, contains fewer harmful mutations that contribute to the development of obesity, and not because they have more willpower and take better control of themselves. Apparently, our weight is not subservient to us as much as we thought.